When do experiments on human life-extension begin - it is often reported that they have extended the life of nematodes or mice, but when will it be used in humans?

When do experiments on human life-extension begin - it is often reported that they have extended the life of nematodes or mice, but when will it be used in humans?

Can You Age Backwards? Dr. David Sinclair Explains Epigenetic Reprogramming & Life Extension · #135

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answers (2)

Answer 1
September, 2021

Experiments to increase life expectancy, in fact, are in full swing in humans. Various diets, lifestyle changes, medical procedures, freezing are tested. But, it is problematic to draw any definite conclusions from these studies, because the average life expectancy of a person exceeds 70 years, and the number of accidents that can affect the outcome is extremely large, respectively, the creation of an RCT in which one group will be given the intended intervention from birth or from a certain date, and the second is a placebo, and it is almost impossible to track life expectancy (as far as I know, no such study has yet been conducted, for purely technical reasons).

For this reason, studies on in real humans are observations (prospective or retrospective studies), about which one can only write "factor A is associated with longevity", or experiments in which the effect of a drug tested in animals on a process that shortens longevity (huge number of medical studies).

None of these designs allow to say unequivocally that A increases a person's lifespan, respectively, such studies, as a rule, are not particularly reviewed in the media, because they are either negative, or complex, or boring, so the public sees reviews of the results of preclinical tests on laboratory animals in which the expected life expectancy does not exceed 2-3 years, and in experiments on which you can get what journalists need - the conclusion that this thing increases life expectancy. You can call this situation publication bias in the media.

Answer 2
September, 2021

Usually such experiments on people are prohibited, for example, as with cloning, no one has cloned people. However, when all the properties of these drugs are found out, they will certainly give them to people, eventually dare.

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