What is more harmful to the body - to drink rarely, but a lot, or often, but a little bit? (the "do not drink" option is not considered)

Without harm to the body, you can use a single dose equivalent to 15 ml of pure ethanol. This is 1 shot of vodka (30 ml), 1 glass of wine (100 ml), or 1 mug of beer (250 ml).

It depends on how rare and how much) Drinking a very large amount of alcohol at once can also lead to various health problems, such as pancreatitis, and in English there is even a separate term for this - binge drinking. Chronic use also has a lot of consequences, so it's difficult to judge which is worse. The risk of cirrhosis is higher in chronic cirrhosis, and studies show that brain damage occurs faster with single high doses of alcohol (including because the neurotransmitter glutamate, which is toxic to neurons in high doses, is actively released).