What happens if you make 15 pieces of Mantoux at once in one hand?

What happens if you make 15 pieces of Mantoux at once in one hand?

Tuberculin Skin Test

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answers (2)

Answer 1
June, 2021

well, you will look like a man who has stung several bees in his hand. can you tell your mother when she asks "what's wrong with your hand?" can you tell me that you decided to conduct a scientific experiment and make 15 manta rays at once

Answer 2
June, 2021

The Mantoux / Pirquet / tuberculin test (hereinafter referred to as PT) does not contain tuberculosis mycobacteria, but their, let's say, characteristic proteins (and other biologically active substances), which together form a mixture called tuberculin. At first glance, there is no danger, is there? But this is only true for small doses, which are administered in one standard sample.

Let's delve a little deeper into the basics of immunology; Whoever is sure that he himself knows, skip this and the next paragraph right away - I must warn everyone else that I am greatly simplifying. There is such a thing as an antigen - they carry all sorts of bacteria, and they are high molecular weight (this is the main word here) proteins / polysaccharides. There are antibodies - they seem to suit antigens, but only if the latter are sufficiently voluminous and weighty. Antibodies in response to infection or the introduction of other foreign substances into the body (in any of these cases, antigens are present) are produced by the immune system and then transferred to the surface of immune cells, for example. With a new hit of antigen-carrying microorganisms or antigenic substances themselves, the reaction to them of immunity will happen much faster than the first time, so the previously synthesized antibodies will immediately interact with them.

Tuberculin is not a full-fledged antigen, it is a hapten - new antibodies for it will definitely not be synthesized, but the old ones will still interact. In fact, everything is more complicated, but these are unnecessary details. Then, if the body was previously sensitized with tuberculosis (there was contact with it; even if a person is not sick now, he still carries antibodies after contact), an antigen complex (in this case, hapten - tuberculin) is formed - an antibody on the immune cell. And then the fun begins. As a result of an antigen-antibody reaction, immunity cells carrying antibodies will be destroyed, biologically active substances, inflammatory mediators, will be released from them, and will enter the tissues. Thus, they will cause a local reaction in the form of hyperemia (redness), infiltration (a lump, which is most often seen after the Mantoux reaction) or a pustule / vesicle (something that looks like a ball from a burn).

And now let's think about it. With one test, local inflammation occurs without serious consequences. But with the introduction of several samples, inflammation may develop all over the limb at once. A general reaction may even happen - shock or, even worse, collapse - depending on the sensitivity of the carrier of antibodies to tuberculosis to its antigens in new doses.

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