Food Supplements E are too broad a generalization to speak of harm or benefit. Exxxx is simply a numeric code that has been assigned to certain chemicals. Some of them have certain harm to health, some do not. Some of these substances have restrictions, some are prohibited in different countries. at the same time, it is necessary to understand that the prohibition of a particular additive or its permissibility does not necessarily indicate harm or benefit (for example, many additives are prohibited simply because there is not enough data on their use and consequences, and many additives are allowed, including in developed countries, but can be harmed if abused).
If you really want to get hung up on supplements, google the lists with numbers, pick your scariest supplements and look for them on the labels. There are no cooked products (bread, dairy products, pasta, confectionery, etc., etc.) without food additives.
And by the way, vitamins E and C are also food additives (E300 and E306).