Well, if you are determined to die in the shortest possible time, then it is better to get stoned before that, expand well, and further down the list - it’s more interesting. More sensations. And if you are going to live happily ever after, then it is better not to start at all. Let my opponents try to peck me here, but I will say: there are no guarantees that the very first try of any drug will not become the end or the beginning of the slippery slide leading to the end for you. Rather the opposite. This is because each type of drug has so many different "hooks" with which it can hook that I could read a whole lecture about them here. If you're interested, I'll read it, but only upon request.
It's not worth dying at all. Is it worth trying drugs? Depends on what. I do not recommend opiates, pharmacy rubbish is there as well as spice. The rest is optional. If not, why torture yourself? And if it pulls, then you will still try without my messages. Good luck.