You can cheat, but not for long. Alcohol or analgesics, for example, can help reduce the pain threshold. But so that forever is unlikely to work. And this is at least impractical, because pain plays an important role in the body and is often the first sign of illness.
You can deceive both by physical intervention in the brain and the use of special substances.
On the network you can find experiments on cockroaches and mice, in which electrodes were connected to their brains and thus the animals felt exactly what it was necessary for scientists.
Substances are drugs. During the Cold War, the USSR and the United States conducted a series of experiments to create super soldiers. Including, they experienced the influence of drugs on the pain sensations of people.