Is there a cure for HIV?

There are two points.

1. It is almost impossible to completely cure HIV, at the moment there are literally two or three cases associated, if not confusing, with bone marrow transplantation to patients, when HIV, in principle, ceased to be fixed in the body. And I'm afraid that a very, very decent time should pass before such treatment is put on stream - https://www.rbc.ru/rbcfreenews/5e69a8aa9a79475ab2f6a922

2. It has long been possible to minimize the negative impact of HIV on the human body - now the quality of life of people with HIV receiving correct treatment is practically not inferior to the quality of life of ordinary people. A significant number of antiretroviral therapy drugs have been developed that reduce the so-called viral load in human blood to almost zero and prevent the transmission of the virus to other people, they essentially put the virus into a dormant mode.

You can read more about this, for example, on the WHO website -

https://www.who.int/ru/news-room/fact-sheets/detail/hiv- aids

And I can also recommend, probably, the not so long ago sensational film by Yuri Dud, dedicated to the topic of HIV in Russia - https://www.youtube.com/watch?v=GTRAEpllGZo

Today (August 2020) HIV infection is an incurable disease. There is no cure for HIV completely. There are drugs that relieve a person from AIDS symptoms, raise immunity, reduce the risk of transmitting infection to another person, improve the quality of life to the highest possible level, almost as if he never had a human immunity virus.

You need to take such drugs daily. Unfortunately, they have many side effects, among them nausea, diarrhea, headache. Treatment should be under the supervision of an infectious disease doctor at the AIDS Center (!!!), who will select a safe regimen and observe the response of the virus and the body to the effects of drugs.

Until recently, only one drug was used for this purpose. But the problem is that HIV is highly mutagenic, which allows it to quickly adapt to adverse conditions and produce viable mutations, continuing to attack healthy cells of the immune system.

To solve this problem, tritotherapy has been developed - a combination of three to four drugs, the action of which suppresses the virus at all stages of development, including its mutations.

Tritotherapy involves a combination of drugs of the following groups.

• Reverse transcriptase inhibitors of two types - nucleoside and non-nucleoside.

• Protease inhibitors.

• Integrase inhibitors.

• Fusion inhibitors.

• Receptor inhibitors.

Today, active research is underway to create another group of drugs. It has no name yet, but it is planned that these will be mutagens for HIV, which will cause the accumulation of errors in the genome of the virus, thereby disrupting its life cycle and causing premature death. Perhaps reprogramming the virus will provide the key to completely curing the infection.

In addition to the ability to mutate, the virus is highly resistant to antiretroviral therapy drugs. If the drug is not correctly selected, or is taken irregularly, or in the wrong doses, then the virus becomes resistant to the drug and its further use does not give a positive result.

HIV resistance leads to the emergence of viral strains initially resistant to HAART. Gradually, resistance mutations accumulate and actively spread, which makes it difficult to conduct therapy and accelerates the onset of the AIDS stage.

Given the resistance of the virus, triple therapy is carried out according to a clear schedule, which suggests that the HIV-infected patient must take the medicine several times a day , at a strictly defined time. Any deviations from the schedule, self-increasing or decreasing the dose are unacceptable!

Naturally, not every patient can comply with this regimen, which significantly reduces the effectiveness of therapy and casts doubt on the entire treatment. Therefore, new HAART regimens are being actively developed, includingsingle dose of the drug per day. The following drugs have already been approved for a single dose: Atazanavir, Abacavir, Didanosine, Tenofovir, Lamivudine, Emtricitabine, Efavirenz and other antiretroviral drugs.

The side effects of antiretroviral drugs are another problem with which experts and their patients collide. Some of the side effects appear almost immediately, which makes it possible to adjust HAART, while the other part leads to serious consequences. Pathology can develop secretly for several years.

Just a few examples of drugs and their side effects.

• Nevirapine - can provoke the development of liver cirrhosis and Stevens syndrome.

• Stavudine - can cause the development of lactic acidosis, hyperlipidemia and lipodystrophy.

• Zidovudine - provokes pancreatitis, bone marrow suppression, anemia, gastrointestinal disorders.

Side effects create an additional burden on the patient's body. To avoid this, it is necessary to regularly examine all organs and systems of an HIV-infected person and, if necessary, adjust HAART.

The availability of HAART is a global problem for all patients. The drug for HIV infection is not commercially available. It is issued in specialized medical institutions. All treatment costs are covered by funds from the federal and regional budgets. Patients receive drugs free of charge, however, due to funding problems and the complexity of the procurement procedure, there are periodic interruptions in the supply of necessary drugs. And given the fact that they must be taken by the patient daily and at a strictly defined time, a situation arises in which the effectiveness of HAART is significantly reduced.

Having missed only 1-2 doses of the drug, the patient needs to adjust the tritotherapy - prescribe other drugs, often of a stronger effect and at a higher cost.

Today there is a functional cure and sterilization.

With a functional cure, the number of viruses is suppressed to a level undetectable by modern equipment. This can be achieved temporarily with a properly prescribed antiretroviral AIDS drug (ARV) regimen.

With a sterilization cure, HIV is completely removed from all parts of the body. There are 3 people in the world (Berlin, London and Dusseldorf patients) who actually recovered from HIV infection in this way.

Timothy Brown ("The Berlin Patient") suffered from leukemia (leukemia) and for its treatment in 2007 he was prescribed chemotherapy and a bone marrow transplant from a donor who had natural resistance to HIV (0.3% of the population are resistant to HIV). Although it is not yet clear why he was cured. The bone marrow transplant procedure itself is very dangerous and cannot be widely used to treat AIDS.

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Therefore, all statements like “I treat HIV / CPID "with 100% guarantee, are fraudulent and can be regarded as misleading and fraudulent in relation to HIV-positive patients.

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In addition to creating a medicine, scientists are improving and methods of HIV prevention. In mid-2016, a large-scale experiment was completed by specialists from the National Institutes of Health (USA). They have developed a vaginal ring with Dapivirin, which should reduce the risk of HIV infection during unprotected intercourse.

The study was conducted by women from South Africa, Uganda, Zimbabwe and Malawi - countries where traditional HIV prevention methods have failed. Women at risk were selected to participate in the experiment. For the purity of the experiment, they were divided into 2 groups, one of which received a vaginal ring with Dapivirin, and the other received a placebo.

According to the results of the study, it was found that the use of a ring with the drug reduces the risk of infection by 27%.

Good afternoon. There is no medicine that would completely cure HIV. Today there is antiretroviral therapy (ART), which allows you to support the body by preventing the virus from multiplying in the body. ARVT lowers the viral load to "undetectable" due to which an HIV-positive person cannot transmit the virus to his sexual partner, it also allows one to live indefinitely as without HIV infection.

Alas and ah.

It is impossible to cure HIV, but you can stop its transmission if you take ART.

Usually the dream of a panacea occurs in the first years after the status has been established, but then, later 10-20 years old, you humble yourself understand that not everything is so scary.

It depends on what is meant by the concept of "cure for HIV." - viral infection and other persistent chronic viral diseases.

There are drugs that, by acting on the virus (directly or indirectly), are able to suppress its activity and help to reduce the manifestations of the disease or prevent exacerbations. However, a complete sanitation of the body does not occur.