It is difficult to answer the question that is posed like this. Because there is no clear line between "regularly" and "periodically". For example, when a person is drinking for a week, sober for three weeks, and then another week of drinking, is it periodically or regularly?
If a person takes an amphetamine weekend once a month, is it periodically? But regularly too?
As for the quantity, it is again unclear. A glass of red wine every day is generally healthy, but much more regularly?
Of course not. The consumption of alcoholic beverages does not cause any harm to the human body. The harm is caused by the disease - alcoholism. Tobacco smoking - yes, it is harmful. But it's damn nice.