There may not be a physiological dependence, but a psychological one will certainly arise. And this already affects the consciousness of a person, in the first place. "Why live a gray life when you can decorate it without any harm to health?" Further, the organism will get used to the substance and the need for the frequency and number of dosages will increase. Nothing will change, drug addicts will remain drug addicts, and if organ damage does not destroy a person, then stress and the like can cause disorders of the body's functions. IMHO.
Yes, it is possible. Moreover, already. All the phenylethylamine derivatives that you can see in the picture are not physically addictive and do not harm your health. However, if we take into account the psychological component, then harm will take place, but provided that you use more often than once every three to four weeks.
First, you need to understand that almost everything around can be harmful if you use it too much and often. Even tea!
Next: you need to define the concept of "drug". What do you mean by this word? Take, for example, Chinese tea: it has an active effect on a person's sensations - it can strongly invigorate or relax, it can be addictive - in fact, you want to drink it more and more, because it has wonderful effects, it is very different, and it is very tasty. These are all the effects that, I believe, you are ready to attribute to the drug: addiction, active influence on the attitude, right? At the same time, Chinese tea is very beneficial for the body. In this case, we get a useful drug.
At the same time, too much of this tea can also be harmful, and this can be attributed to almost any product available for consumption.
No, even if we assume that there is a certain substance that does not harm human health, and from it you can make a drug, it will be addictive. Not so much physical as psychological. The person will be addicted to the drug, which gives a clouding of his mind, the ability to get away from daily problems. And the thought that it is not harmful to his health will only increase this addiction.
For starters, nothing is completely harmless. Even water with the best drinking qualities can lead to poisoning and death if drunk enough.
And so, LSD has no physical side effects, for example. There are so micro doses that there is no harmful effect on the body. Well, except that the brain enters a freelance mode of work and does not always come back out.