I know for sure that Phenibut and alcohol go very badly together. This is supported by research and many bad cases. I don't know about smoking.
friend, I really do not recommend it. Once I was on therapy and took toxic drugs, the body was already overloaded.
but there was one small misfire, I smoked one cigarette while taking medicines. God forbid you experience what happened to me then, a breakdown of the immune and nervous system with months (half a year) of recovery.
Phenibut is certainly not so chemically complex, but the load on the body and nervous system will be very strong, but you will not even notice, especially when the body begins to fall apart, subjectively for yourself it is imperceptible
I don't know what about nootropic action, but Phenibut is an anxiolytic, and they increase inebriation. It has no effect on smoke. In general, no pills should be mixed with booze, especially paracetamol, antidepressants, sleeping pills and trunks can die.