Can a transplanted organ “get sick” again?

Can a transplanted organ “get sick” again?

ID Issues Pre and Post Solid Organ Transplantation - Rachel Irby, MD

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answers (2)

Answer 1
January, 2021

The transplanted organ is the same as its own, even without proper care it can get sick, and do not forget about the high probability of rejection (but this is probably the worst outcome, it is better not to think about it)

Answer 2
January, 2021

Doctors always assess the risk of a return of the original disease, due to which the patient required a transplant. Fortunately, in most cases, repeat is not possible.

Let me explain with an example: due to a defect in the genes, the human liver did not produce an enzyme, this led to the development of the disease and subsequent transplantation. The donor liver will produce enzymes normally because it depends on the recipient's genetic makeup.

But diseases associated with an increased immunological response - autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cirrhosis, glomerulonephritis - can recur in the graft. In these cases, post-transplant immunosuppression is the prevention of not only rejection, but also the recurrence of the original disease. We prevent the return of diseases such as cirrhosis of the liver of viral etiology with timely antiviral therapy.

And, of course, transplanted organs are threatened by the same diseases as non-transplanted ones. Therefore, everyone should be attentive to their health and nutrition, give up bad habits, and be systematically monitored at the transplant center.

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